MCDB News:

Image of chromosomes

October 21, 2015

Induced pluripotent stem cells (iPSCs) grown from the skin cells of a person with Down syndrome are helping researchers grow cerebral organoids and track protein expression in an effort to better understand the disorder on a cellular and molecular level. University of Colorado Boulder postdoc Tristan McClure-Begley and his colleagues sought to better understand the neurological and developmental changes that occur in people with a third copy of chromosome 21, the unifying pathological feature of Down syndrome. “That third copy of chromosome 21 influences all aspects of embryonic development, including critical steps during brain development,” McClure-Begley said in a statement. “But we’ve had trouble identifying exactly why the extra chromosome has such widespread effects, partly because we’ve lacked good human tissue models of Down syndrome.”
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