The Detweiler Lab



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Detweiler Publications on PubMed (Click Here for Link)

A new way to beat intestinal pathogens.

Detweiler CS. Trends Microbiol
PMID: 28139374

Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA.
McQuate SE, Young AM, Silva-Herzog E, Bunker E, Hernandez M, de Chaumont F, Liu X, Detweiler CS, Palmer AE. Cell Microbiol 2017.
PMID: 27376507

meningitis associated with monocyte infiltration in mice.
Bauler TJ, Starr T, Nagy TA, Sridhar S, Scott D, Winkler CW, Steele-Mortimer O, Detweiler CS, Peterson KE. Am J Pathol 2017.

Physiologic stresses reveal a Salmonella persister state and TA family toxins modulate tolerance to these stresses.

Silva-Herzog E, McDonald EM, Crooks AL, Detweiler CS. PLoS One 2015.
PMID: 26633172

Bacterial stimulation of Toll-Like Receptor 4 drives macrophages to hemophagocytose.
McDonald EM, Pilonieta MC, Nick HJ, Detweiler CS. Infect Immun 2015.
PMID: 26459510

Increased ferroportin-1 expression and rapid splenic iron loss occur with anemia caused by Salmonella infection in mice.
Brown DE, Nick HJ, McCoy MW, Moreland SM, Stepanek AM, Benik R, O'Connell KE, Pilonieta MC, Nagy TA, Detweiler CS. Infect Immun 2015;83(6):2290-9.
PMID: 25824831

The biomechanisms of metal and metal-oxide nanoparticles' interactions with cells.
Teske SS, Detweiler CS. Int J Environ Res Public Health 2015;12(2):1112-34.
PMID: 25648173

Salmonella enterica
infection stimulates macrophages to hemophagocytose.
Pilonieta MC, Moreland SM, English CN, Detweiler CS. MBio 2014; 5(6):e02211-14.
PMID: 25491357

Salmonella acquires ferrous iron from haemophagocytic macrophages.
Nagy TA, Moreland SM, Detweiler CS. Mol Microbiol 2014; 93(6):1314-26.
PMID: 25081030

The ferric enterobactin transporter Fep is required for persistent Salmonella enterica serovar typhimurium infection.

Nagy TA, Moreland SM, Andrews-Polymenis H, Detweiler CS. Infect Immun 2013; 81(11):4063-70.
PMID: 23959718

Salmonella enterica causes more severe inflammatory disease in C57/BL6 Nramp1G169 mice than Sv129S6 mice.
Brown DE, Libby SJ, Moreland SM, McCoy MW, Brabb T, Stepanek A, Fang FC, Detweiler CS. Vet Pathol 2013; 50(5): 867-76.
PMID: 23446432

Hemophagocytic macrophages in murine typhoid fever have an anti-inflammatory phenotype.
McCoy MW, Moreland SM, Detweiler CS. Infect Immun 2012; 80(10):3642-9.
PMID: 22868497

A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production.
Pilonieta MC, Nagy TA, Jorgensen DR, Detweiler CS. Mol Microbiol 2012; 84(2):296-309.
PMID: 22375627

Salmonella enterica replication in hemophagocytic macrophages requires two type three secretion systems.

Silva-Herzog E, Detweiler CS. Infect Immun 2010; 78(8):3369-77.
PMID: 20515933

Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis.

Brown DE, McCoy MW, Pilonieta MC, Nix RN, Detweiler CS. PLoS One 2010; 5(2):e9441.
PMID: 20195482

A protein important for antimicrobial peptide resistance, Ydel/OmdA, is in the periplasm and interacts with OmpD/NmpC.
Pilonieta MC, Erickson KD, Ernst RK, Detweiler CS. J Bacteriol 2009; 191(23):7243-52.
PMID: 19767429

Intracellular microbes and haemophagocytosis.
Silva-Herzog E, Detweiler CS. Cell Microbiol 2008; 10(11):2151-8.
PMID: 18616693

Hemophagocytic macrophages harbor Salmonella enterica during persistent infection.
Nix RN, Altshucler SE, Henson PM, Detweiler CS. PLoS Pathog 2007; 3(12):e193.
PMID: 18085823

Cross-species cluster co-conservation: a new method for generating protein interaction networks.
Karimpour-Fard A, Detweiler CS, Erickson KD, Hunter L, Gill RT. Genome Biol 2007; 8(9):R185.
PMID: 17803817

The Rcs phosphorelay system is specific to enteric pathogens/commensals and activate ydel, a gene important for persistent Salmonella infection of mice.
Erickson KD, Detweiler CS. Mol Microbiol 2006; 62(3):883.94.
PMID: 17010160

Microarray analysis and motif detection reveal new targets of the Salmonella enterica serovar Typhimurium HilA regulatory protein, including hilA itself.
De Keersmaecker SC, Marchal K, Verhoeven TL, Engelen K, Vanderleyden J, Detweiler CS. J Bacteriol 2005; 187(13)4381-91.
PMID: 15968047

virK, somA and rcsC are important for system Salmonella enterica serovar Typhimurium infection and cationic peptide resistance.
Detweiler CS, Monack DM, Brodsky IE, Mathew H, Falkow S. Mol Microbiol 2003; 48(2):385-400.
PMID: 12675799

Genomic comparison of Salmonella enterica serovars and Salmonella bongori by use of an S. enterica serovar Typhimurium DNA microarray.
Chan K, Baker S, Kim CC, Detweiler CS, Dougan G, Falkow S. J Bacteriol 2003; 185(2):553-63.
PMID: 12511502

Salmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1.
Monack DM, Detweiler CS, Falkow S. Cell Microbiol 2001; 3(12):825-37.
PMID: 11736994

Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death.
Detweiler CS, Cunanan DB, Falkow S. Proc Natl Acad Sci USA 2001; 98(10):5850-5.
PMID: 11320214

OmpR regulates the two-component system SsrA-ssrB in Salmonella pathogenicity island 2.
Lee AK, Detweiler CS, Falkow S. J Bacteriol 2000; 182(3):771-81.
PMID: 10633113

Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae.
Detweiler CS, Li JJ. Proc Natl Acad Sci USA 1998; 95(5):2384-9.
PMID: 9482894

CDC45 is required in conjuction with CDC7/DBF4 to trigger the initiation of DNA replication.

Owens JC, Detweiler CS, Li JJ. Proc Natl Acad Sci USA 1997; 94(23):12521-6.
PMID: 9356482

Cdc6p establishes and maintains a state of replication competence during G1 phase.

Detweiler CS, Li JJ. J Cell Sci 1997; 110(Pt 6):753-63.
PMID: 9099949

Detweiler Lab | The Publications
Updated 9 December 2015.