Photo of Larry Gold

Larry Gold

Porter room B428B
Visit the Gold Foundation website.
Explore Larry Gold's areas of research and more in Vivo


Research Interests:
SELEX / aptamers.

Research Profile:
SELEX (Systematic Evolution of Ligands by Exponential enrichment) is a combinatorial chemistry methodology in which vast numbers of oligonucleotides (DNA, RNA, or unnatural compounds) are screened rapidly for specific sequences that have appropriate binding affinities and specificities toward any target. SELEX also has been used to identify new ribozymes and deoxyribozymes.

Selected Publications

Driving forces in cancer diagnostics.
Gander, TR, Brody, EN, Mehler, RE, Heilig, JS, Singer, BS, and Gold, L MLO Med Lab Obs, 35(1):10-6, 20; quiz 20-1. 2003

Aptamers as therapeutic and diagnostic agents.
Brody, EN and Gold, L J Biotechnol, 74(1):5-13. 2000

A specific RNA structural motif mediates high affinity binding by the HIV-1 nucleocapsid protein (NCp7).
Allen, P, Collins, B, Brown, D, Hostomsky, Z, and Gold, L Virology, 225(2):306-15. 1996

In vitro evolution of intrinsically bent DNA.
Beutel, BA and Gold, L J Mol Biol, 228(3):803-12. 1992

Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation.
Winter, RB, Morrissey, L, Gauss, P, Gold, L, Hsu, T, and Karam, J Proc Natl Acad Sci U S A, 84(22):7822-6. 1987