Porter room B428B
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Explore Larry Gold's areas of research and more in Vivo
SELEX / aptamers.
SELEX (Systematic Evolution of Ligands by Exponential enrichment) is a combinatorial chemistry methodology in which vast numbers of oligonucleotides (DNA, RNA, or unnatural compounds) are screened rapidly for specific sequences that have appropriate binding affinities and specificities toward any target. SELEX also has been used to identify new ribozymes and deoxyribozymes.
Driving forces in cancer diagnostics.
Gander, TR, Brody, EN, Mehler, RE, Heilig, JS, Singer, BS, and Gold, L MLO Med Lab Obs, 35(1):10-6, 20; quiz 20-1. 2003
Aptamers as therapeutic and diagnostic agents.
Brody, EN and Gold, L J Biotechnol, 74(1):5-13. 2000
A specific RNA structural motif mediates high affinity binding by the HIV-1 nucleocapsid protein (NCp7).
Allen, P, Collins, B, Brown, D, Hostomsky, Z, and Gold, L Virology, 225(2):306-15. 1996
In vitro evolution of intrinsically bent DNA.
Beutel, BA and Gold, L J Mol Biol, 228(3):803-12. 1992
Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation.
Winter, RB, Morrissey, L, Gauss, P, Gold, L, Hsu, T, and Karam, J Proc Natl Acad Sci U S A, 84(22):7822-6. 1987